Antiproliferative agent-11

Antiproliferative agent-11 (compound 7) is an antiproliferative and selective Ruthenium (II) -Tris-pyrazolylmethane complex. Antiproliferative agent-11 shows antiproliferative activity towards MCF-7, HeLa, 518A2, HCT116 and RD with IC50s of 6, 10, 6.8, 6.7 and 6 μM, respectively. Antiproliferative agent-11 can be used for the research of cancer[1].

Product Specifications

CAS Number

[9007-83-4]

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/antiproliferative-agent-11.html

Solubility

10 mM in DMSO

Smiles

[H]c12n3cccn3[Ru+](n4n2ccc4)(Cl)([P](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)([P](OC)(OC)OC)n8n1ccc8.[Cl-]

Molecular Formula

C31H34Cl2N6O3P2Ru

Molecular Weight

772.56

References & Citations

[1]Cervinka J, et al. Ruthenium (II) -Tris-pyrazolylmethane Complexes Inhibit Cancer Cell Growth by Disrupting Mitochondrial Calcium Homeostasis. J Med Chem. 2022 Aug 1.