RAD51-IN-8

RAD51-IN-8, a new RAD51 binder, is a RAD51-BRCA2 inhibitor that inhibits the RAD51 BRCA2 protein protein interaction. RAD51-IN-8 also is a protein protein interaction (PPI) inhibitor. RAD51-IN-8 has inhibitory activity for H4A4 with an EC50 value of 19 μM[1].

Product Specifications

UNSPSC

12352005

Target

RAD51

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rad51-in-8.html

Solubility

10 mM in DMSO

Smiles

O=C(N/N=C/C1=CC=CN=C1F)CCCOC2=CC=C(Cl)C=C2Cl

Molecular Formula

C16H14Cl2FN3O2

Molecular Weight

370.21

References & Citations

[1]Greta Bagnolini, et al. Identification of RAD51–BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry. ACS Med. Chem. Lett. 2022.