RAD51-IN-8
RAD51-IN-8, a new RAD51 binder, is a RAD51-BRCA2 inhibitor that inhibits the RAD51 BRCA2 protein protein interaction. RAD51-IN-8 also is a protein protein interaction (PPI) inhibitor. RAD51-IN-8 has inhibitory activity for H4A4 with an EC50 value of 19 μM[1].
Product Specifications
UNSPSC
12352005
Target
RAD51
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rad51-in-8.html
Solubility
10 mM in DMSO
Smiles
O=C(N/N=C/C1=CC=CN=C1F)CCCOC2=CC=C(Cl)C=C2Cl
Molecular Formula
C16H14Cl2FN3O2
Molecular Weight
370.21
References & Citations
[1]Greta Bagnolini, et al. Identification of RAD51–BRCA2 Inhibitors Using N-Acylhydrazone-Based Dynamic Combinatorial Chemistry. ACS Med. Chem. Lett. 2022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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