BTK ligand 1

BTK ligand 1 (compound 1) is a ligand targeting Bruton’s tyrosine kinase (Btk) . BTK ligand 1 can combine with E3 ligase ligand (Ligand for E3 Ligase) through PROTAC Linker to form PROTAC. PROTACs targeting Btk can be used in the study of chronic lymphocytic leukemia (CLL) and other BK cell malignancies[1].

Product Specifications

CAS Number

[330785-90-5]

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Btk; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/btk-ligand-1.html

Solubility

10 mM in DMSO

Smiles

NC1=NC=NC2=C1C(C3=CC=C(OC4=CC=CC=C4)C=C3)=NN2C5CCNCC5

Molecular Formula

C22H22N6O

Molecular Weight

386.45

Precautions

H315, H319, H320

References & Citations

[1]Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57 (26) :3564-3575.