BTK ligand 1
BTK ligand 1 (compound 1) is a ligand targeting Bruton’s tyrosine kinase (Btk) . BTK ligand 1 can combine with E3 ligase ligand (Ligand for E3 Ligase) through PROTAC Linker to form PROTAC. PROTACs targeting Btk can be used in the study of chronic lymphocytic leukemia (CLL) and other BK cell malignancies[1].
Product Specifications
CAS Number
330785-90-5
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Btk; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btk-ligand-1.html
Solubility
10 mM in DMSO
Smiles
NC1=NC=NC2=C1C(C3=CC=C(OC4=CC=CC=C4)C=C3)=NN2C5CCNCC5
Molecular Formula
C22H22N6O
Molecular Weight
386.45
Precautions
H315, H319, H320
References & Citations
[1]Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57 (26) :3564-3575.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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