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HDAC ligand-1

HDAC ligand-1 is a HDAC ligand that can be used to synthesize PROTAC HDAC degraders, such as compounds 21a and 21b in references[1].

Product Specifications

CAS Number

34840-28-3

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

HDAC; Ligands for Target Protein for PROTAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac-ligand-1.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

NC1=CC=CC=C1NC=O

Molecular Formula

C7H8N2O

Molecular Weight

136.15

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Yingxin Lu, et al. Design, Synthesis, and Biological Evaluation of HDAC Degraders with CRBN E3 Ligase Ligands. Molecules. 2021 Nov 29;26 (23) :7241.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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