HDAC ligand-1
HDAC ligand-1 is a HDAC ligand that can be used to synthesize PROTAC HDAC degraders, such as compounds 21a and 21b in references[1].
Product Specifications
CAS Number
34840-28-3
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
HDAC; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-ligand-1.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
NC1=CC=CC=C1NC=O
Molecular Formula
C7H8N2O
Molecular Weight
136.15
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Yingxin Lu, et al. Design, Synthesis, and Biological Evaluation of HDAC Degraders with CRBN E3 Ligase Ligands. Molecules. 2021 Nov 29;26 (23) :7241.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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