FLDP-5
FLDP-5 is a blood-brain barrier (BBB) penetrant curcuminoid analogues. FLDP-5 can induce production of ROS (Reactive Oxygen Species), DNA damage and cell cycle S phase arrest. FLDP-5 exhibits highly potent tumour-suppressive effects with anti-proliferative and anti-migratory activities on LN-18 cells[1].
Product Specifications
CAS Number
950665-12-0
UNSPSC
12352005
Target
DNA/RNA Synthesis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fldp-5.html
Solubility
10 mM in DMSO
Smiles
O=C1/C(CNC/C1=C\C2=CC=C(O)C(OC)=C2)=C/C3=CC=C(O)C(OC)=C3
Molecular Formula
C21H21NO5
Molecular Weight
367.40
References & Citations
[1]Razali NSC, et al. Curcumin piperidone derivatives induce anti-proliferative and anti-migratory effects in LN-18 human glioblastoma cells. Sci Rep. 2022 Jul 30;12 (1) :13131.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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