BMS-986339

BMS-986339 is an orally active, potent FXR agonist. BMS-986339 forms H-bond with His298 and ASN287 residues. BMS-986339 can be used in the research of primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and nonalcoholic steatohepatitis (NASH), anti-fibrosis[1].

Product Specifications

CAS Number

[2477873-64-4]

UNSPSC

12352005

Target

Cytochrome P450; FXR

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bms-986339.html

Solubility

10 mM in DMSO

Smiles

CC(F)(C1=NC(C23CCC(CC2)(CC3)CN(C4=CC(C5=CC=C(C=C5)C(C)(O)C)=CC=C4)C([C@H]6C[C@@](O)(C6)C(F)(F)F)=O)=NO1)C

Molecular Formula

C35H41F4N3O4

Molecular Weight

643.71

References & Citations

[1]Susheel J Nara, et al. Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2022 Jul 14;65 (13) :8948-8960.