BMS-986339
BMS-986339 is an orally active, potent FXR agonist. BMS-986339 forms H-bond with His298 and ASN287 residues. BMS-986339 can be used in the research of primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), and nonalcoholic steatohepatitis (NASH), anti-fibrosis[1].
Product Specifications
CAS Number
[2477873-64-4]
UNSPSC
12352005
Target
Cytochrome P450; FXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bms-986339.html
Solubility
10 mM in DMSO
Smiles
CC(F)(C1=NC(C23CCC(CC2)(CC3)CN(C4=CC(C5=CC=C(C=C5)C(C)(O)C)=CC=C4)C([C@H]6C[C@@](O)(C6)C(F)(F)F)=O)=NO1)C
Molecular Formula
C35H41F4N3O4
Molecular Weight
643.71
References & Citations
[1]Susheel J Nara, et al. Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2022 Jul 14;65 (13) :8948-8960.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP2
Curated Selection
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