HDAC6/HSP90-IN-2

HDAC6/HSP90-IN-2 (compound 6e) is a dual inhibitor of HDAC6 and Hsp90, with IC50s of 105.7 and 61 nM, respectively. HDAC6/HSP90-IN-2 can be used for the research of cancer[1].

Product Specifications

CAS Number

[2803866-22-8]

UNSPSC

12352005

Target

Apoptosis; HDAC; HSP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac6-hsp90-in-2.html

Solubility

10 mM in DMSO

Smiles

OC1=C(C(C)C)C=C(C(N(C)CC2=CC=C(C=C2)C(NO)=O)=O)C(O)=C1

Molecular Formula

C19H22N2O5

Molecular Weight

358.39

References & Citations

[1]Chae HY, et al. Design, synthesis, and biological evalution of bifunctional inhibitors against Hsp90-HDAC6 interplay. Eur J Med Chem. 2022 Jul 6;240:114582.