Tubulin/HDAC-IN-1

Tubulin/HDAC-IN-1 is a dual tubulin and HDAC-IN-1 inhibitor through CH/π interaction with tubulin and hydrogen bond interaction with HDAC8. Tubulin/HDAC-IN-1 inhibits tubulin polymerization and selectively inhibits HDAC8 (IC50: 150 nM) . Tubulin/HDAC-IN-1 has cytotoxicity against various human cancer cells, also arrests cell cycle in the G2/M phase and induces cell apoptosis. Tubulin/HDAC-IN-1 can be used in the research of hematologic and solid tumors such as neuroblastoma, leukemia[1].

Product Specifications

CAS Number

[2413587-26-3]

UNSPSC

12352005

Target

Apoptosis; HDAC; Microtubule/Tubulin; Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tubulin-hdac-in-1.html

Solubility

10 mM in DMSO

Smiles

CN(C1=CC=C(OC)C(/C=C/C(NO)=O)=C1)C2=CC(C#N)=NC3=C2C=CC=C3

Molecular Formula

C21H18N4O3

Molecular Weight

374.39

References & Citations

[1]Camille Hauguel, et al. Design, synthesis and biological evaluation of quinoline-2-carbonitrile-based hydroxamic acids as dual tubulin polymerization and histone deacetylases inhibitors. Eur J Med Chem. 2022 Jul 1;240:114573.