GSK5852
GSK5852 (GSK2485852) is an HCV NS5B polymerase inhibitor, with an IC50 value of 50 nM. GSK5852 displays antiviral activity and inhibits HCV with EC50s of 3.0 nM (genotype 1a, GT1a) and 1.7 nM (GT1b), respectively[1][2][3].
Product Specifications
CAS Number
1331942-30-3
Product Name Alternative
GSK2485852
UNSPSC
12352005
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk5852.html
Solubility
10 mM in DMSO
Smiles
FC1=CC(CN(C2=CC3=C(C=C2C4CC4)C(C(NC)=O)=C(C5=CC=C(C=C5)F)O3)S(C)(=O)=O)=CC=C1B(O)O
Molecular Formula
C27H25BF2N2O6S
Molecular Weight
554.37
References & Citations
[1]Zhou Z, et al. Small molecule NS5B RdRp non-nucleoside inhibitors for the treatment of HCV infection: A medicinal chemistry perspective. Eur J Med Chem. 2022 Jul 8. 240:114595. |[2]Voitenleitner C, et al. In vitro characterization of GSK2485852, a novel hepatitis C virus polymerase inhibitor. Antimicrob Agents Chemother. 2013 Nov;57 (11) :5216-24. |[3]Maynard A, et al. Discovery of a potent boronic acid derived inhibitor of the HCV RNA-dependent RNA polymerase. J Med Chem. 2014 Mar 13;57 (5) :1902-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Frequently Asked Questions
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