Topo I/COX-2-IN-2
Topo I/COX-2-IN-2 (Compound W10) is a potent dual-target inhibitor of Topo I and COX-2 with IC50 values of 0.90 μM and 2.31 μM, respectively. Topo I/COX-2-IN-2 induces cancer cell apoptosis through the mitochondrial pathway[1].
Product Specifications
CAS Number
2841455-91-0
UNSPSC
12352005
Target
Apoptosis; COX; Reactive Oxygen Species (ROS) ; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topo-i-cox-2-in-2.html
Solubility
10 mM in DMSO
Smiles
ClC1=C(C(NC2=CC=CC=C2C(NC3=CC=C(C=C3)N4CCNCC4)=O)=CC=C1)C
Molecular Formula
C24H25ClN4O
Molecular Weight
420.93
References & Citations
[1]Hu X, et al. Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy. Eur J Med Chem. 2022 Jun 23;240:114560.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2; Topo I
Frequently Asked Questions
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