BTK-IN-15
BTK-IN-15 (compound 42) is a potent Bruton's tyrosine kinase (BTK) inhibitor with high oral absorption. BTK-IN-15 inhibits BTK with an IC50 value of 0.7 nM. BTK-IN-15 displays excellent kinase selectivity, antitumor activity, and induces apoptosis[1].
Product Specifications
CAS Number
2820426-92-2
UNSPSC
12352005
Target
Btk; Pyroptosis
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btk-in-15.html
Solubility
10 mM in DMSO
Smiles
O=C(C=C)N1CCC(C2=CNC3=NC=NC(C4=CC=C(CNC(C5=CC=CC=C5)=O)C(F)=C4)=C23)=CC1
Molecular Formula
C28H24FN5O2
Molecular Weight
481.52
References & Citations
[1]Minjian Yang, et al. Design, synthesis, and biological evaluation of pyrrolopyrimidine derivatives as novel Bruton's tyrosine kinase (BTK) inhibitors. EUR J MED. 2022 Jul. 114611.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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