IRAK4-IN-18
IRAK4-IN-18 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 value of 15 nM. IRAK4-IN-18 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-18 can be used for researching arthritis disease[1].
Product Specifications
CAS Number
[3032075-26-3]
UNSPSC
12352005
Target
IRAK
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/irak4-in-18.html
Solubility
10 mM in DMSO
Smiles
O=C(N)[C@@H]1[C@@H]([C@@H]2C[C@H]1C=C2)NC3=NC(NC4=CC(N5CCOCC5)=CC(F)=C4)=NC6=C3OC=C6
Molecular Formula
C24H25FN6O3
Molecular Weight
464.49
References & Citations
[1]Chen Y, et al. Bicyclic pyrimidine compounds as potent IRAK4 inhibitors. Bioorg Med Chem Lett. 2022 Jul 18:128900.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK4
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