AChE-IN-22
AChE-IN-22 (compound 10q) is a selective acetylcholinesterase (AChE) inhibitor against AChE and BuChE with the IC50 values of 0.88 μM and 10 μM, respectively. AChE-IN-22 can bind to both the CAS (catalytic active site) and PAS (peripheral anionic site) of AChE and has the potential for the research of Alzheimer's disease[1].
Product Specifications
CAS Number
3032264-62-0
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-22.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CS1)CC2=NC=C(C=N2)C(N(CCCOC3=CC=C(C=C3)[N+]([O-])=O)C)=O
Molecular Formula
C21H20N4O5S
Molecular Weight
440.47
References & Citations
[1]Chuang Han, et al. Design, synthesis and evaluation of 2- (2-oxoethyl) pyrimidine-5-carboxamide derivatives as acetylcholinesterase inhibitors. Bioorg Med Chem Lett. 2022 Sep 15;72:128873.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
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