SIRT5 inhibitor 4
SIRT5 inhibitor 4 (compound 11) is a potent, selective SIRT5 inhibitor with IC50 values of 26.4 and >400μM for SIRT5 and other SIRT subtype, respectively[1].
Product Specifications
CAS Number
[708992-34-1]
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt5-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
CC(NC(C=C1)=CC=C1C2=CSC(NC3=CC=C(C(O)=O)C(O)=C3)=N2)=O
Molecular Formula
C18H15N3O4S
Molecular Weight
369.39
References & Citations
[1]Han LY, et, al. Identification of 2-hydroxybenzoic acid derivatives as selective SIRT5 inhibitors. Eur.J.Med.Chem.2022 Jul 22, 114623
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT1; SIRT2; SIRT3; SIRT5; SIRT6; SIRT7
Available Sizes
Curated Selection
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