TXA6101

TXA6101 is a bacterial protein FtsZ (filamentous temperature-sensitive protein Z) inhibitor that inhibits bacterial division. TXA6101 has antimicrobial activity against MRSA isolates expressing either the G193D or G196S mutant FtsZ with the MIC value of 1 μg/mL, retains significant activity against the TXA707-resistant FtsZ mutant. TXA6101 can be used as a potential method against Gram-negative bacterial infections[1][2].

Product Specifications

CAS Number

1459695-66-9

UNSPSC

12352005

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/txa6101.html

Solubility

10 mM in DMSO

Smiles

O=C(N)C1=C(F)C=CC(OCC2=NC(C3=CC=C(C(F)(F)F)C=C3)=C(Br)O2)=C1F

Molecular Formula

C18H10BrF5N2O3

Molecular Weight

477.18

References & Citations

[1]Andrea Casiraghi, et al. Targeting Bacterial Cell Division: A Binding Site-Centered Approach to the Most Promising Inhibitors of the Essential Protein FtsZ. Antibiotics (Basel) . 2020 Feb 7;9 (2) :69.|[2]Junso Fujita, et al. Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ. ACS Chem Biol. 2017 Jul 21;12 (7) :1947-1955.|[3]Jesus D Rosado-Lugo, et al. Evaluation of 2,6-difluoro-3- (oxazol-2-ylmethoxy) benzamide chemotypes as Gram-negative FtsZ inhibitors. J Antibiot (Tokyo) . 2022 Jul;75 (7) :385-395.