JAK3-IN-13
JAK3-IN-13 (compound 12n) is a potent, selective and orally active JAK3 inhibitor with IC50 values of 4728, 2039, 8, 365 nM for NK1, JNK2, JNK3, Tyk2, respectively. JAK3-IN-13 shows antiproliferative activity. JAK3-IN-13 induces cell cycle arrest at G0/G1 phase. JAK3-IN-13 shows antitumor activity[1].
Product Specifications
CAS Number
[2803329-86-2]
UNSPSC
12352005
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jak3-in-13.html
Solubility
10 mM in DMSO
Smiles
C=CC(NC1=CC(NC2=NC=C(Cl)C(O[C@H]3[C@](OC[C@H]4OC)([H])[C@]4([H])OC3)=N2)=CC=C1N(CCN(C)C)C)=O
Molecular Formula
C25H33ClN6O5
Molecular Weight
533.02
References & Citations
[1]Li S, et al. Discovery of Hexahydrofuro[3,2-b]furans as New Kinase-Selective and Orally Bioavailable JAK3 Inhibitors for the Treatment of Leukemia Harboring a JAK3 Activating Mutant. J Med Chem. 2022 Jul 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK1; JNK2; JNK3
Curated Selection
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