Topo I/COX-2-IN-1
Topo I/COX-2-IN-1 (1H-30) is a potential Topo I/COX-2 inhibitor. Topo I/COX-2-IN-1 inhibits COX-2 and Topo I with the IC50 value of 0.24 μM and 4.42 μM, respectively. Topo I/COX-2-IN-1 can induce apoptosis and inhibit migration of cancer cells, has anti-cancer activity[1].
Product Specifications
CAS Number
3031418-84-2
UNSPSC
12352005
Target
Apoptosis; Prostaglandin Receptor; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/topo-i-cox-2-in-1.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C=CC=C1NC2=CC=C(C=C2C(NCC3=CC=C(C(O)=C3)O)=O)F)Cl
Molecular Formula
C21H18ClFN2O3
Molecular Weight
400.83
References & Citations
[1]Junfang Li, et al. N-2- (Phenylamino) Benzamide Derivatives as Dual Inhibitors of COX-2 and Topo I Deter Gastrointestinal Cancers via Targeting Inflammation and Tumor Progression. J Med Chem. 2022 Jul 22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo I
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