FGFR-IN-8
FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC50 values of apoptosis and shows anticancer activities[1].
Product Specifications
CAS Number
2640217-64-5
UNSPSC
12352005
Target
Apoptosis; FGFR
Type
Reference compound
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr-in-8.html
Solubility
10 mM in DMSO
Smiles
CC(N1CCC(N2N=CC(NC3=NC(C4=CC=CN=C4NC5=C(Cl)C(OC)=CC(OC)=C5Cl)=NC=N3)=C2)CC1)C
Molecular Formula
C27H31Cl2N9O2
Molecular Weight
584.50
References & Citations
[1]Ryu S, et al. Identification of Pyridinyltriazine Derivatives as Potent panFGFR Inhibitors against Gatekeeper Mutants for Overcoming Drug Resistance. J Med Chem. 2022 Apr 28;65 (8) :6017-6038.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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