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FGFR-IN-8

FGFR-IN-8 (Compound 17a) is a highly potent and orally active panFGFR inhibitor against wild-type and mutant FGFRs. FGFR-IN-8 shows inhibition with IC50 values of apoptosis and shows anticancer activities[1].

Product Specifications

CAS Number

2640217-64-5

UNSPSC

12352005

Target

Apoptosis; FGFR

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fgfr-in-8.html

Solubility

10 mM in DMSO

Smiles

CC(N1CCC(N2N=CC(NC3=NC(C4=CC=CN=C4NC5=C(Cl)C(OC)=CC(OC)=C5Cl)=NC=N3)=C2)CC1)C

Molecular Formula

C27H31Cl2N9O2

Molecular Weight

584.50

References & Citations

[1]Ryu S, et al. Identification of Pyridinyltriazine Derivatives as Potent panFGFR Inhibitors against Gatekeeper Mutants for Overcoming Drug Resistance. J Med Chem. 2022 Apr 28;65 (8) :6017-6038.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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