RSK2-IN-2
RSK2-IN-2 (Compound 25) is a reversible covalent inhibitor of the RPS6KA3 (RSK2) kinase. RSK2-IN-2 is also described to inhibit MSK1, MSK2 and RSK3[1].
Product Specifications
CAS Number
1637749-78-0
UNSPSC
12352005
Target
Ribosomal S6 Kinase (RSK)
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rsk2-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N)/C(C#N)=C/C1=CC=CC(C2=C3C(NC=C3)=NC=N2)=C1
Molecular Formula
C16H11N5O
Molecular Weight
289.29
References & Citations
[1]Hall A, et al. Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1. ACS Med Chem Lett. 2022 Jun 25;13 (7) :1099-1108.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RSK2; RSK3
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