KDM4-IN-4
KDM4-IN-4 (compound 47) is a potent histone lysine demethylase 4 (KDM4) inhibitor with a modest affinity binding to ~80 μM for KDM4A-Tudor domain. KDM4-IN-4 can inhibit H3K4Me3 binding to the Tudor domain in cells with an EC50 value of 105 μM. KDM4-IN-4 can be used for researching anticancer[1].
Product Specifications
CAS Number
2230475-63-3
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kdm4-in-4.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@@]2(C3=CC=CC=C3)C[C@H](CC2)[C@@H]1CN(C)C
Molecular Formula
C16H23NO
Molecular Weight
245.36
References & Citations
[1]Wu Q, Young B, Wang Y, Davidoff AM, Rankovic Z, Yang J. Recent Advances with KDM4 Inhibitors and Potential Applications. J Med Chem. 2022 Jul 15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM4
Available Sizes
Frequently Asked Questions
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