(Rac) -Lartesertib
(Rac) -Lartesertib ((Rac) -M4076) is an isoform of Lartesertib (HY-150617) . Lartesertib (M4076) is an inhibitor of the serine/threonine protein kinase ATM with high potency. Lartesertib can inhibit the growth of multiple hematopoietic cell lines. Additionally, when combined with the ATR inhibitor Tuvusertib (HY-111451), Lartesertib can promote the death of tumor cells, activate the immune signaling pathway, and exhibit anti-tumor activity[1][2].
Product Specifications
CAS Number
[2020089-41-0]
Product Name Alternative
(Rac) -M4076; (Rac) -ATM Inhibitor-5
UNSPSC
12352005
Target
ATM/ATR; PD-1/PD-L1; STING
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/rac-lartesertib.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=C(N1C)C=NC3=C2C=C(C4=CN(C)N=C4C)C(OC)=C3)C5=C(OC)C=NC=C5F
Molecular Formula
C23H21FN6O3
Molecular Weight
448.45
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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