SphK1-IN-2
SphK1-IN-2 is a potent, selective SphK1 inhibitor with IC50 values of 19.81 nM and > 10 μM for SphK1 and SphK2, respectively. SphK1-IN-2 exhibits anti-proliferative activities and induces cell cycle arrest and apoptosis. SphK1-IN-2 can be used for cancer research[1].
Product Specifications
CAS Number
3031483-60-7
UNSPSC
12352005
Target
Apoptosis; SphK
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sphk1-in-2.html
Solubility
10 mM in DMSO
Smiles
OC[C@@H]1N(CC2=CC=C(COC3=CC(CS(=O)(C4=CC=CC=C4)=O)=C(Br)C(C)=C3)C=C2)CCC1
Molecular Formula
C27H30BrNO4S
Molecular Weight
544.50
References & Citations
[1]Zhang S, et, al. Novel Sphingosine Kinase 1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-Negative Breast Cancer. J Med Chem. 2022 Jun 9;65 (11) :7697-7716.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SphK1; SphK2
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