Autotaxin-IN-6

Autotaxin-IN-6 (compound 23) is a potent autotaxin (ATX) inhibitor with an IC50 value of 30 nM. Autotaxin-IN-6 can reduce cell migration. Autotaxin-IN-6 can be used for researching anticancer[1].

Product Specifications

CAS Number

[2800898-98-8]

UNSPSC

12352005

Target

LPL Receptor; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/autotaxin-in-6.html

Purity

99.88

Solubility

10 mM in DMSO

Smiles

O[C@@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CCC(N4CCC(CC4)OC5=CC=C(C=C5)B(O)O)=O)C)([H])[C@@]6([C@](C[C@@H](CC6)O)([H])C1)C

Molecular Formula

C35H54BNO6

Molecular Weight

595.62

References & Citations

[1]Clark JM, et al. Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators. J Med Chem. 2022 Apr 28;65 (8) :6338-6351.