NS2B/NS3-IN-7

NS2B/NS3-IN-7 (compound 26) is a highly potent Zika virus NS2B-NS3 protease inhibitor with a Ki value of 2.33 nM. NS2B/NS3-IN-7 can reduce amounts of ZIKV-infected cells[1].

Product Specifications

CAS Number

[3035421-16-7]

UNSPSC

12352005

Target

Flavivirus; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ns2b-ns3-in-7.html

Solubility

10 mM in DMSO

Smiles

NCCCC[C@@H](C(N[C@H]1CCCCN)=O)NC(CC2=CC=CC(CNC([C@@H](CCC3CCCCC3)NC([C@@H](CCCCNC1=O)NC(N)=N)=O)=O)=C2)=O

Molecular Formula

C38H64N10O5

Molecular Weight

740.98

References & Citations

[1]Huber S, et al. Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors. J Med Chem. 2022 May 12;65 (9) :6555-6572.