20S Proteasome-IN-3
20S Proteasome-IN-3 is a 20S proteasome β5 subunit inhibitor (IC50=1.64 μM) [1][2]. 20S Proteasome-IN-3 shows anti-tumor proliferation activity[2].
Product Specifications
CAS Number
1803040-07-4
UNSPSC
12352005
Target
Proteasome
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/20s-proteasome-in-3.html
Solubility
10 mM in DMSO
Smiles
OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CC(C)C)C(C2=CC=CO2)=O)=O)NC([C@@H](NC(OC(C)(C)C)=O)CC3=CC=C(C=C3)OC)=O
Molecular Formula
C34H43N3O8
Molecular Weight
621.72
References & Citations
[1]Qi Sun, et al. Design and synthesis of tripeptidyl furylketones as selective inhibitors against the β5 subunit of human 20S proteasome. Eur J Med Chem. 2020 Apr 15;192:112160.|[2]Qi Sun, et al. Synthesis, bioactivity, docking and molecular dynamics studies of furan-based peptides as 20S proteasome inhibitors. ChemMedChem. 2015 Mar;10 (3) :498-510.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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