Anti-inflammatory agent 31
Anti-inflammatory agent 31 (enone 17) is a kind of andrographolide derivatives, is a anti-inflammatory agent. Anti-inflammatory agent 31 inhibits NF-κB activation by upstream blockade of PI3K/Akt and ERK1/2 MAPK activation. Anti-inflammatory agent 31 shows recovery effective of the intracellular GSH levels and protective effect on liver[1].
Product Specifications
CAS Number
3051838-54-8
UNSPSC
12352211
Target
ERK; NF-κB
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-31.html
Solubility
10 mM in DMSO
Smiles
CC(/C=C/C[C@@H]1C(CC[C@]2([H])[C@](C)(CO)[C@H](O)CC[C@@]12C)=C)=O
Molecular Formula
C19H30O3
Molecular Weight
306.44
References & Citations
[1]Tran QTN, Tan DWS, Wong WSF, Chai CLL. From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action. Eur J Med Chem. 2020 Oct 15;204:112481.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERK1; ERK2
Frequently Asked Questions
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