BuChE-IN-5

BuChE-IN-5 (compound 25b) is a potent BuChE inhibitor with an IC50 value of 1.94 μM. BuChE-IN-5 efficiently inhibits aggregation Aβ and tau protein in Escherichia coli. BuChE-IN-5 also has free radical scavenging capacity and antioxidant activity. BuChE-IN-5 can be used for researching Alzheimer’s disease[1].

Product Specifications

CAS Number

[2402753-39-1]

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE) ; Tau Protein

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/buche-in-5.html

Solubility

10 mM in DMSO

Smiles

N1(CC2=CC=CC=C2)CC(NCCN3CC(CC4=CC=CC=C4)CCC3)CC1

Molecular Formula

C25H35N3

Molecular Weight

377.57

References & Citations

[1]Wichur T, et al. 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease. Eur J Med Chem. 2020 Feb 1;187:111916.