Chitin synthase inhibitor 2

Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B[1].

Product Specifications

CAS Number

[2416338-24-2]

UNSPSC

12352005

Target

Antibiotic; Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/chitin-synthase-inhibitor-2.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1C(NC2=C(C=CC=C2)C1)=O)/C=C/C(NC3=CC=CC(C)=C3)=O

Molecular Formula

C20H19N3O3

Molecular Weight

349.38

References & Citations

[1]Li B, Shen Y, Wu H, Wu X, Yuan L, Ji Q. Design, synthesis and biological evaluation of novel 3,4-dihydro-2 (1H) -quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2020 Jun 1;195:112278.