Chitin synthase inhibitor 2
Product Specifications
UNSPSC Description
Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B[1].
Target Antigen
Antibiotic; Fungal
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/chitin-synthase-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1C(NC2=C(C=CC=C2)C1)=O)/C=C/C(NC3=CC=CC(C)=C3)=O
Molecular Weight
349.38
References & Citations
[1]Li B, Shen Y, Wu H, Wu X, Yuan L, Ji Q. Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2020 Jun 1;195:112278.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150583/Chitin-synthase-inhibitor-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150583/
Clinical Information
No Development Reported
CAS Number
2416338-24-2
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