Keap1-Nrf2-IN-12
Keap1-Nrf2-IN-12 is a potent Keap1-Nrf2 inhibitor with an IC50 value of 2.30 μM. Keap1-Nrf2-IN-12 shows metabolic stability in human liver microsomes[1].
Product Specifications
CAS Number
2250082-04-1
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-12.html
Solubility
10 mM in DMSO
Smiles
O=S(N(CC(O)=O)CC1=CC=CC=C1CN(CC(O)=O)S(=O)(C2=CC=C(OC)C=C2)=O)(C3=CC=C(OC)C=C3)=O
Molecular Formula
C26H28N2O10S2
Molecular Weight
592.64
References & Citations
[1]Abed DA, et al. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem. 2020 Mar 15;28 (6) :115343.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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