Keap1-Nrf2-IN-12

Keap1-Nrf2-IN-12 is a potent Keap1-Nrf2 inhibitor with an IC50 value of 2.30 μM. Keap1-Nrf2-IN-12 shows metabolic stability in human liver microsomes[1].

Product Specifications

CAS Number

[2250082-04-1]

UNSPSC

12352005

Target

Keap1-Nrf2

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/keap1-nrf2-in-12.html

Solubility

10 mM in DMSO

Smiles

O=S(N(CC(O)=O)CC1=CC=CC=C1CN(CC(O)=O)S(=O)(C2=CC=C(OC)C=C2)=O)(C3=CC=C(OC)C=C3)=O

Molecular Formula

C26H28N2O10S2

Molecular Weight

592.64

References & Citations

[1]Abed DA, et al. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem. 2020 Mar 15;28 (6) :115343.