HDAC-IN-45
Product Specifications
UNSPSC Description
HDAC-IN-45 (Compound 14) is a small molecule HDAC inhibitor and has anticancer activity, also can forms a hydrogen
bond with residue Y303. HDAC-IN-45 (Compound 14) has substantial inhibitory effects towards HDAC1, 2 and 3 isoforms with IC50 values of 0.108, 0.585 and 0.563 μM respectively[1].
Target Antigen
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-45.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC=C1N)C2=CC=C(CN3C=NC4=C(NC5=CC=C(F)C(Cl)=C5)N=C(N)N=C34)C=C2
Molecular Weight
502.93
References & Citations
[1]Kunal Nepali, et al. Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors. Eur J Med Chem. 2020 Jun 15;196:112291.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150577/HDAC-IN-45-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150577/
Clinical Information
No Development Reported
CAS Number
2421122-61-2
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS610776-01 0.1 mg
Acid Sensitive Ion Channel 2b (ASIC2B, MDEG2, Mammalian Degenerin2)
Ask
View Details 
MBS610776-02 5x 0.1 mg
Acid Sensitive Ion Channel 2b (ASIC2B, MDEG2, Mammalian Degenerin2)
Ask
View Details LY416738 100 µg
valyl tRNA synthetase (VARS) (NM_006295) Human Over-expression Lysate
Ask
View Details 