Carbonic anhydrase inhibitor 14
Carbonic anhydrase inhibitor 14 (Compound 8b) is a carbonic anhydrase (CA) inhibitor with Ki values of 1203, 99.7, 9.4 and 27.7 nM against hCA I, hCA II, hCA IX and hCA XII, respectively. Carbonic anhydrase inhibitor 14 can also inhibit CDK2 with an IC50 of 20.3 μM. Carbonic anhydrase inhibitor 14 shows antitumor activity[1].
Product Specifications
CAS Number
2410402-75-2
UNSPSC
12352005
Target
Carbonic Anhydrase; CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/carbonic-anhydrase-inhibitor-14.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(/N=N/C2=C(NC(C3=CC=C(C)C=C3)=C4)N4N=C2N)C=C1)(N)=O
Molecular Formula
C18H17N7O2S
Molecular Weight
395.44
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CA II; CA I; CA IX; CA XII; CDK2
Frequently Asked Questions
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