SIRT1/2/3-IN-1
Product Specifications
CAS Number
2413212-06-1
UNSPSC Description
SIRT1/2/3-IN-1 (compound 10) is a highly potent, selective and cell permeable inhibitor of SIRT1, SIRT2 and SIRT3 with IC50s of 0.54, 0.253, and 0.72 μM, respectively. SIRT1/2/3-IN-1 (compound 10) can be used for research of cancer[1].
Target Antigen
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sirt1-2-3-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC1=O)CCSC)NCCCCCOC2=CC=C(C=C2)C[C@@H]1NC([C@H](CCCCNC(C)=S)NC([C@@H]3CC4=CC=C(OCCCC(N[C@H](C(N3)=O)CC5=CN=CN5)=O)C=C4)=O)=O
Molecular Weight
934.18
References & Citations
[1]Li R , et al. A bicyclic pentapeptide-based highly potent and selective pan-SIRT1/2/3 inhibitor harboring Nε-thioacetyl-lysine[J]. Bioorganic & Medicinal Chemistry, 2020, 28(7):115356.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Frequently Asked Questions
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