P-gp inhibitor 5

Product Specifications

UNSPSC Description

P-gp inhibitor 5 is a potent P-glycoprotein (P-gp) inhibitor. P-gp inhibitor 5 has antiproliferative activity against certain cancer cell lines. P-gp inhibitor 5 is effective in reversing the multidrug resistance (MDR) phenotype in ABCB1/Flp-InTM-293 and KBvin cells by restoring their sensitivity to Vincristine (HY-N0488A) and Paclitaxel (HY-B0015)[1].

Target Antigen

P-glycoprotein

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/p-gp-inhibitor-5.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=C(C2=CC=CS2)C3=C(OC(C)=O)C=C(C4=CC=C(OC)C=C4)C=C3O1)C5=CC=CC=C5Cl

Molecular Weight

517.98

References & Citations

[1]Hung CC, et al. Synthesis and biological evaluation of thiophenylbenzofuran derivatives as potential P-glycoprotein inhibitors. Eur J Med Chem. 2020 Sep 1;201:112422.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-150565/P-gp-inhibitor-5-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-150565/

Clinical Information

No Development Reported

CAS Number

2451298-06-7

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