Neuroinflammatory-IN-2
Product Specifications
UNSPSC Description
Neuroinflammatory-IN-2 is a potent anti-neuroinflammatory agent with an IC50 value of 10.30 μM for MAO-B, and 96.33% inhibition of Aβ1-42 aggregation at 25 μM. Neuroinflammatory-IN-2 has neuroprotective activity in H2O2-induced PC-12 cell injury. Neuroinflammatory-IN-2 also has biometal chelating abilities, antioxidant activity, anti-neuroinflammatory activity and appropriate BBB permeability. Neuroinflammatory-IN-2 can be used for researching Alzheimer’s disease[1].
Target Antigen
Amyloid-β; Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/neuroinflammatory-in-2.html
Solubility
10 mM in DMSO
Smiles
CC(C1=CC=C(C2=CC=C(NCC3=CC(N(C)C)=CC=C3O)C=C2)C(F)=C1)C(OC)=O
Molecular Weight
422.49
References & Citations
[1]Yang Z, et al. Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer's disease. Bioorg Med Chem. 2020 Apr 1;28(7):115374.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150563/Neuroinflammatory-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150563/
Clinical Information
No Development Reported
CAS Number
2361384-14-5
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