COX-2-IN-28
COX-2-IN-28 is a potent and selective COX-2 inhibitor with IC50 values of 0.054, 2.14, 13.21 μM for COX-2, 15-LOX, COX-1, respectively[1].
Product Specifications
CAS Number
2413565-18-9
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-in-28.html
Solubility
10 mM in DMSO
Smiles
C/C(CNC1=NC(N2C(SC)=NC3=CC=CC=C23)=CS1)=N\N=C4SC=C(C5=CC=C(C)C=C5)N/4C6=CC=CC=C6
Molecular Formula
C30H27N7S3
Molecular Weight
581.78
References & Citations
[1]Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28 (7) :115403.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
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