COX-2-IN-26
COX-2-IN-26 is a potent, selective and orally active COX-2 inhibitor with IC50 values of 10.61, 0.067, 1.96 μM for COX-1, COX-2, 15-LOX, respectively. COX-2-IN-26 shows anti-inflammatory activity. COX-2-IN-26 shows gastrointestinal safety profile[1].
Product Specifications
CAS Number
2413565-19-0
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-in-26.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=CC=CC=C2)/C(SC1)=N\N=C(CNC3=NC(N4C(SC)=NC5=C4C=CC=C5)=CS3)/C
Molecular Formula
C23H21N7OS3
Molecular Weight
507.65
References & Citations
[1]Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28 (7) :115403.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
Frequently Asked Questions
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