HIV-1 protease-IN-6
HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC50 of 21 pM and a Ki of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir) -resistant variant, even more than wild type virus[1].
Product Specifications
CAS Number
2892016-32-7
UNSPSC
12352005
Target
HIV; HIV Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hiv-1-protease-in-6.html
Solubility
10 mM in DMSO
Smiles
CC(CN(S(=O)(C1=CC=C(C=C1)F)=O)C[C@H]([C@@H](NC(C2=CC(O)=CC(O)=C2)=O)CC3=CC=CC=C3)O)C
Molecular Formula
C27H31FN2O6S
Molecular Weight
530.61
References & Citations
[1]Hu S, et al. A kind of HIV-1 protease inhibitors containing phenols with antiviral activity against DRV-resistant variants. Bioorg Med Chem. 2022 Jun 15. 64:116760.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIV-1
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