HIV-1 protease-IN-6

HIV-1 protease-IN-6 (compound 17d) is a potent HIV-1 protease inhibitor, with an IC50 of 21 pM and a Ki of 4.7 pM, respectively. HIV-1 protease-IN-6 exhibits potent antiviral activity to DRV (darunavir) -resistant variant, even more than wild type virus[1].

Product Specifications

CAS Number

[2892016-32-7]

UNSPSC

12352005

Target

HIV; HIV Protease

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hiv-1-protease-in-6.html

Solubility

10 mM in DMSO

Smiles

CC(CN(S(=O)(C1=CC=C(C=C1)F)=O)C[C@H]([C@@H](NC(C2=CC(O)=CC(O)=C2)=O)CC3=CC=CC=C3)O)C

Molecular Formula

C27H31FN2O6S

Molecular Weight

530.61

References & Citations

[1]Hu S, et al. A kind of HIV-1 protease inhibitors containing phenols with antiviral activity against DRV-resistant variants. Bioorg Med Chem. 2022 Jun 15. 64:116760.