COX-2/15-LOX-IN-1
COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity[1].
Product Specifications
CAS Number
2413565-15-6
UNSPSC
12352005
Target
COX; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-15-lox-in-1.html
Solubility
10 mM in DMSO
Smiles
S=C(NC1=CC=CC=C1)N/N=C(C)/CNC2=NC(N3C(SC)=NC4=CC=CC=C34)=CS2
Molecular Formula
C21H21N7S3
Molecular Weight
467.63
References & Citations
[1]Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28 (7) :115403.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
15-LOX; COX-1; COX-2
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