COX-2/15-LOX-IN-1

COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity[1].

Product Specifications

CAS Number

[2413565-15-6]

UNSPSC

12352005

Target

COX; Lipoxygenase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-2-15-lox-in-1.html

Solubility

10 mM in DMSO

Smiles

S=C(NC1=CC=CC=C1)N/N=C(C)/CNC2=NC(N3C(SC)=NC4=CC=CC=C34)=CS2

Molecular Formula

C21H21N7S3

Molecular Weight

467.63

References & Citations

[1]Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28 (7) :115403.