AChE-IN-21
AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro[1].
Product Specifications
CAS Number
2413656-04-7
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-21.html
Solubility
10 mM in DMSO
Smiles
O=C1O/C(C2=C1C=C(OC)C(OC)=C2)=C\CCCCCN(CC3=CC=CC=C3)C
Molecular Formula
C24H29NO4
Molecular Weight
395.49
References & Citations
[1]Luo L, et al. Design, synthesis and evaluation of phthalide alkyl tertiary amine derivatives as promising acetylcholinesterase inhibitors with high potency and selectivity against Alzheimer's disease. Bioorg Med Chem. 2020 Apr 15;28 (8) :115400.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LS359845 100 µg
FAM101B (RFLNB) (NM_182705) Human Over-expression Lysate
Sign In for Pricing
View Details 
orb3110335 100 µg
Dynamin 1/DNM1 Rabbit Polyclonal Antibody (Fluoro647)
Sign In for Pricing
View Details 