Bcl-2-IN-10
Bcl-2-IN-10 is an active Bcl-2 inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research[1].
Product Specifications
CAS Number
2773354-28-0
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bcl-2-in-10.html
Solubility
10 mM in DMSO
Smiles
O=[N+](C1=CC([N+]([O-])=O)=C(C=C1)O/N=[N+](N2CCC(CC2)CN3CCN(CC3)/N=[N+](OC4=C(C=C(C=C4)[N+]([O-])=O)[N+]([O-])=O)\[O-])\[O-])[O-]
Molecular Formula
C22H25N11O12
Molecular Weight
635.50
References & Citations
[1]Xun Ji, et al. Double-component diazeniumdiolate derivatives as anti-cancer agents. Bioorg Med Chem. 2020 Apr 15;28 (8) :115405.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax
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