AChE/GSK-3β-IN-1

AChE/GSK-3β-IN-1 (compound GT15) is a potent, dual AChE/GSK-3β inhibitor with IC50 values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3β, respectively. AChE/GSK-3β-IN-1 penetrates the blood-brain barrier (BBB) . AChE/GSK-3β-IN-1 has high kinase selectivity profiles for the CMGC kinase family. AChE/GSK-3β-IN-1 occupies the ATP binding site of DYRK1A. AChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. AChE/GSK-3β-IN-1 can be used for Alzheimer’s disease research[1].

Product Specifications

CAS Number

[2412364-73-7]

UNSPSC

12352005

Target

Cholinesterase (ChE) ; GSK-3; Microtubule/Tubulin; ROS Kinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Neuronal Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-gsk-3β-in-1.html

Solubility

10 mM in DMSO

Smiles

CNC(C(S1)=C(N=C1C2=CC(NC(CNCCNC3=C4CCCCC4=NC5=CC=CC=C35)=O)=NC=C2)OCC6CC6)=O

Molecular Formula

C31H35N7O3S

Molecular Weight

585.72

References & Citations

[1]Jiang X, et, al. Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease. Eur J Med Chem. 2020 Dec 1;207:112751.