AChE/GSK-3β-IN-1
Product Specifications
UNSPSC Description
AChE/GSK-3β-IN-1 (compound GT15) is a potent, dual AChE/GSK-3β inhibitor with IC50 values of 1.2, 149.8 and 22.4 nM for hAChE , hBChE and hGSK-3β, respectively. AChE/GSK-3β-IN-1 penetrates the blood-brain barrier (BBB). AChE/GSK-3β-IN-1 has high kinase selectivity profiles for the CMGC kinase family. AChE/GSK-3β-IN-1 occupies the ATP binding site of DYRK1A. AChE/GSK-3β-IN-1 inhibits ROS expression and reduces oxidative stress. AChE/GSK-3β-IN-1 can be used for Alzheimer’s disease research[1].
Target Antigen
Cholinesterase (ChE); GSK-3; Microtubule/Tubulin; ROS Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton;Neuronal Signaling;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-gsk-3β-in-1.html
Solubility
10 mM in DMSO
Smiles
CNC(C(S1)=C(N=C1C2=CC(NC(CNCCNC3=C4CCCCC4=NC5=CC=CC=C35)=O)=NC=C2)OCC6CC6)=O
Molecular Weight
585.72
References & Citations
[1]Jiang X, et, al. Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease. Eur J Med Chem. 2020 Dec 1;207:112751.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150537/AChE-GSK-3β-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150537/
Clinical Information
No Development Reported
CAS Number
2412364-73-7
Curated Selection
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