3- (3-Phenoxybenzyl) amino-β-carboline
3- (3-Phenoxybenzyl) amino-β-carboline is a potent tubulin inhibitor. 3- (3-Phenoxybenzyl) amino-β-carboline promotes selective degradation of αβ-tubulin heterodimers. 3- (3-Phenoxybenzyl) amino-β-carboline induces G2/M phase cell cycle arrest and apoptosis. 3- (3-Phenoxybenzyl) amino-β-carboline exhibits anticancer activity[1].
Product Specifications
CAS Number
1327080-54-5
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/3-3-phenoxybenzyl-amino-β-carboline.html
Solubility
10 mM in DMSO
Smiles
C(N1)(C=NC(NCC2=CC=CC(OC3=CC=CC=C3)=C2)=C4)=C4C5=C1C=CC=C5
Molecular Formula
C24H19N3O
Molecular Weight
365.43
References & Citations
[1]Yang J, et al. Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond. J Med Chem. 2022 Jun 28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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