KCL-440
KCL-440 is a CNS-penetrated PARP inhibitor, with an IC50 of 68 nM. KCL-440 has strong inhibition of PARP-1[1][2].
Product Specifications
CAS Number
651029-09-3
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kcl-440.html
Solubility
10 mM in DMSO
Smiles
O=C1NC=C(C2=CC=C(CN(C)C)C=C2)C3=C(O)C=CC=C31
Molecular Formula
C18H18N2O2
Molecular Weight
294.35
References & Citations
[1]Yasuhiko Ikeda, et al. Neuroprotective effects of KCL-440, a new poly (ADP-ribose) polymerase inhibitor, in the rat middle cerebral artery occlusion model. Brain Res. 2005 Oct 26;1060 (1-2) :73-80.|[2]Tatsushi Kamiya, et al. The neuroprotective effects of a newly synthesized poly (ADP-ribose) polymerase (PARP) inhibitor (KCL-440) on neuronal cell death following transient focal ischemia in rat. Journal of Cerebral Blood Flow & Metabolism. 2005.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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