TSPO ligand-3
TSPO ligand-3 is a ligand of AUTAC2. AUTAC2 contains an p-fluorobenzylguanine (FBnG) and an synthetic ligand of FKBP (SLF) moiety, which can cause significant silencing of FKBP12 in HeLa cells[1].
Product Specifications
CAS Number
2241669-89-4
UNSPSC
12352005
Target
AUTACs
Type
Reference compound
Related Pathways
Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tspo-ligand-3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1N(CCCC1)C(C(C(C)(C)CC)=O)=O)O[C@@H](C2=CC(NC(CCC(O)=O)=O)=CC=C2)CCC3=CC(OC)=C(C=C3)OC
Molecular Formula
C34H44N2O9
Molecular Weight
624.72
References & Citations
[1]Takahashi D, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76 (5) :797-810.e10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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