XF067-68
XF067-68 (example 132) is a PROTAC for targeted degradation of WD40 repeat domain protein 5 (WDR5). XF067-68 can be usde for the study of WDR5-mediated diseases. (Pink: target protein ligand ; Blue: E3 ligase ligand (HY-173627) ; Black: linker (HY-Y0966) ; E3 ligase ligand + linker: HY-176517).
Product Specifications
CAS Number
2407452-79-1
UNSPSC
12352005
Target
PROTACs; WDR5
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/xf067-68.html
Purity
99.56
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C(C(C(F)(F)F)=C1)=CNC1=O)NC2=C(N3C[C@H](N([C@H](C3)C)C)C)C=CC(C4=CC(C(NCC(N[C@@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O)=O)=CC=C4F)=C2
Molecular Formula
C52H59F4N9O7S
Molecular Weight
1030.14
References & Citations
[1]Jian J, et al. Wd40 repeat domain protein 5 (wdr5) degradation/destruction compound and method of use. WO2019246570A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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